解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::We experimentally compare the performance and image contrast of spontaneous Raman and coherent Stokes Raman scattering microscopy. We demonstrate the differences between these techniques on a series of geometry-controlled samples that range in complexity from a point (array of tips) to one-dimensional (line grating) a...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3533310
更新日期:2011-02-01 00:00:00
abstract::We demonstrate that doubly-resonant coherent anti-Stokes Raman scattering can provide enhanced and highly specific contrast for molecules containing unique Raman-active small molecular groups. This combination provides contrast for molecules that can otherwise be difficult to discriminate by Raman spectroscopy. Here, ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3544585
更新日期:2011-02-01 00:00:00
abstract::We present the design and experimental results of a new MEMS-based endoscopic optical coherence tomography (OCT) probe. The uniqueness of this miniature OCT imaging probe is a two-axis MEMS mirror with through-silicon vias (TSVs) for interconnecting. The TSV interconnection enables ultracompact probe design, successfu...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3533323
更新日期:2011-02-01 00:00:00
abstract::Previous studies have shown the ability of many lymphatic vessels to contract phasically to pump lymph. Every lymphangion can act like a heart with pacemaker sites that initiate the phasic contractions. The contractile wave propagates along the vessel to synchronize the contraction. However, determining the location o...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3544512
更新日期:2011-02-01 00:00:00
abstract::Previous works investigated a spectroscopic technique that offered a promising alternative to blood and breath assays for determining in vivo alcohol concentration. Although these prior works measured the dorsal forearm, we report the results of a 26-subject clinical study designed to evaluate the spectroscopic techni...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3535594
更新日期:2011-02-01 00:00:00
abstract::We present a novel Fourier-domain angle-resolved low-coherence interferometry (a /LCI) fiber probe designed for in vivo clinical application in gastrointestinal endoscopy. The a/LCI technique measures the depth-resolved angular scattering distribution to determine the size distribution and optical density of cell nucl...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3520130
更新日期:2011-01-01 00:00:00
abstract::We present the light scattering properties of individual human red blood cells (RBCs). We show that both the RBC static and dynamic scattering signals are altered by adenosine 5'-triphosphate (ATP)-driven membrane metabolic remodeling. To measure the light scattering signal from individual RBCs, we use diffraction pha...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3524509
更新日期:2011-01-01 00:00:00
abstract::To improve surgical guidance toward prostate draining lymph nodes, we investigate the potential of intraoperative fluorescence imaging and combined pre- and intraoperative multimodality imaging approaches. Transgenic adenocarcinoma mouse prostate mice with spontaneous prostate tumors are injected intratumorally with: ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3528027
更新日期:2011-01-01 00:00:00
abstract::We present a simple wide-field imaging technique, called HiLo microscopy, that is capable of producing optically sectioned images in real time, comparable in quality to confocal laser scanning microscopy. The technique is based on the fusion of two raw images, one acquired with speckle illumination and another with st...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3528656
更新日期:2011-01-01 00:00:00
abstract::Near-infrared spectroscopy is a novel imaging technique potentially sensitive to both brain hemodynamics (slow signal) and neuronal activity (fast optical signal, FOS). The big challenge of measuring FOS noninvasively lies in the presumably low signal-to-noise ratio. Thus, detectability of the FOS has been controversi...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3505007
更新日期:2010-11-01 00:00:00
abstract::Anastomotic complication is a major morbidity associated with esophagectomy. Gastric ischemia after conduit creation contributes to anastomotic complications, but a reliable method to assess oxygenation in the gastric conduit is lacking. We hypothesize that fiber optic spectroscopy can reliably assess conduit oxygenat...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3512149
更新日期:2010-11-01 00:00:00
abstract::Time-resolved measurement of early arriving photons through diffusive media has been shown to effectively reduce the high degree of light scatter in biological tissue. However, the experimentally achievable reduction in photon scatter and the impact of time-gated detection on instrument noise performance is not well u...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3523371
更新日期:2010-11-01 00:00:00
abstract::We report the use of spectral Doppler optical coherence tomography imaging (SDOCTI) for quantitative evaluation of dynamic blood circulation before and after a localized ischemic stroke in a mouse model. Rose Bengal photodynamic therapy (PDT) is used as a noninvasive means for inducing localized ischemia in cortical m...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3505016
更新日期:2010-11-01 00:00:00
abstract::The development of methods that allow microscale studies of complex biomaterials based on their molecular composition is of great interest to a wide range of research fields. We show that stimulated Raman scattering (SRS) microscopy is an excellent analytical tool to study distributions of different biomolecules in mu...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3516591
更新日期:2010-11-01 00:00:00
abstract::Different colors of visible light penetrate to varying depths in tissue due to the wavelength dependence of tissue optical absorption and elastic scattering. We exploit this to map the contour of the closest surface of a buried fluorescent object. This uses a novel algorithm based on the diffusion theory description o...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3523369
更新日期:2010-11-01 00:00:00
abstract::We present a method for tissue fluorescence quantification in situ using a handheld fiber optic probe that measures both the fluorescence and diffuse reflectance spectra. A simplified method to decouple the fluorescence spectrum from distorting effects of the tissue optical absorption and scattering is developed, with...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3523616
更新日期:2010-11-01 00:00:00
abstract::Fluorescence imaging for detection of non-muscle-invasive bladder cancer is based on the selective production and accumulation of fluorescing porphyrins-mainly, protoporphyrin IX-in cancerous tissues after the instillation of Hexvix®. Although the sensitivity of this procedure is very good, its specificity is somewhat...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3484257
更新日期:2010-09-01 00:00:00
abstract::The absorption of filter substances in sunscreens, reducing the incident ultraviolet (UV) radiation, is the basis for the protecting ability of such formulations. The erythema-correlated sun protection factor (SPF), depending mainly on the intensity of the UVB radiation, is the common value to quantify the efficacy of...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3497047
更新日期:2010-09-01 00:00:00
abstract::Micrometer scale resolution full-field optical coherence tomography (FF-OCT) is developed for imaging human graft corneas. Three-dimensional (3-D) images with ultrahigh resolution (respectively, 1 and 1.5 μm in the axial and transverse directions), comparable to traditional histological sections, are obtained allowing...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3486544
更新日期:2010-09-01 00:00:00
abstract::Pulse-modulated second harmonic imaging microscopes (PM-SHIMs) exhibit improved signal-to-noise ratio (SNR) over conventional SHIMs on sensitive imaging and quantification of weak collagen signals inside tissues. We quantify the spatial distribution of sparse collagen inside a xenograft model of human acute myeloid le...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3497565
更新日期:2010-09-01 00:00:00
abstract::A primary focus of neurointensive care is monitoring the injured brain to detect harmful events that can impair cerebral blood flow (CBF), resulting in further injury. Since current noninvasive methods used in the clinic can only assess blood flow indirectly, the goal of this research is to develop an optical techniqu...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3488626
更新日期:2010-09-01 00:00:00
abstract::A fully integrated trimodality fluorescence, diffuse optical, and x-ray computed tomography (FT/DOT/XCT) system for small animal imaging is reported in this work. The main purpose of this system is to obtain quantitatively accurate fluorescence concentration images using a multimodality approach. XCT offers anatomical...
journal_title:Journal of biomedical optics
pub_type: 信件
doi:10.1117/1.3467495
更新日期:2010-07-01 00:00:00
abstract::Photodynamic therapy (PDT) is reviewed using the treatment of skin tumors as an example of superficial lesions and prostate cancer as an example of deep-lying lesions requiring interstitial intervention. These two applications are among the most commonly studied in oncological PDT, and illustrate well the different ch...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3466579
更新日期:2010-07-01 00:00:00
abstract::Optical coherence tomography (OCT) can provide new insight into disease progression and therapy by enabling nondestructive, serial imaging of in vivo cancer models. In previous studies, we have shown the utility of endoscopic OCT for identifying adenomas in the azoxymethane-treated mouse model of colorectal cancer and...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3446674
更新日期:2010-07-01 00:00:00
abstract::Monitoring a degranulation process in a live mast cell is a quite important issue in immunology and pharmacology. Because the size of a granule is normally much smaller than the resolution limit of an optical microscope system, there is no direct real-time live cell imaging technique for observing degranulation proces...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3470104
更新日期:2010-07-01 00:00:00
abstract::Ex vivo human skin has been used extensively for cosmeceutical and drug delivery studies, transplantable skin allografts, or skin flaps. However, it has a half-life of a few days due to ischemic necrosis. Traditional methods of assessing viability can be time-consuming and provide limited metabolic information. Using ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3466580
更新日期:2010-07-01 00:00:00
abstract::Microscopic visualization of islets of Langerhans under normal and diabetic conditions is essential for understanding the pathophysiology of the disease. The intrinsic opacity of pancreata, however, limits optical accessibility for high-resolution light microscopy of islets in situ. Because the standard microtome-base...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3470241
更新日期:2010-07-01 00:00:00
abstract::Dihydroartemisinin (DHA), a front-line antimalarial herbal compound, has been shown to possess promising anticancer activity with low toxicity. We have previously reported that DHA induced caspase-3-dependent apoptosis in human lung adenocarcinoma cells. However, the cellular target and molecular mechanism of DHA-indu...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3481141
更新日期:2010-07-01 00:00:00
abstract::Myocardial infarction leads to structural remodeling of the myocardium, in particular to the loss of cardiomyocytes due to necrosis and an increase in collagen with scar formation. Stem cell regenerative treatments have been shown to alter this remodeling process, resulting in improved cardiac function. As healthy myo...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3469844
更新日期:2010-07-01 00:00:00
abstract::This work reports a miniaturized laparoscopic zoom camera that can significantly improve vision for minimally invasive surgery (MIS), also known as laparoscopic surgery. The laparoscopic zoom camera contains bioinspired fluidic lenses that can change curvature and focal length in a manner similar to the crystalline le...
journal_title:Journal of biomedical optics
pub_type: 信件
doi:10.1117/1.3420192
更新日期:2010-05-01 00:00:00
abstract::We present the application of a microfluidic optical cell stretcher to measure the elasticity of malaria-infected red blood cells. The measurements confirm an increase in host cell rigidity during the maturation of the parasite Plasmodium falciparum. The device combines the selectivity and sensitivity of single-cell e...
journal_title:Journal of biomedical optics
pub_type: 信件
doi:10.1117/1.3458919
更新日期:2010-05-01 00:00:00
abstract::We demonstrate the utility of functional near-infrared spectroscopy (fNIRS) as a tool for physicians to study cortical plasticity in children with cerebral palsy (CP). Motor cortex activation patterns were studied in five healthy children and five children with CP (8.4+/-2.3 years old in both groups) performing a fing...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3432746
更新日期:2010-05-01 00:00:00
abstract::Planar glass waveguides with a specific number of modes were fabricated by Ag(+)-Na(+) exchange in Schott SG11 glass. The effective refractive indices were determined using m-line spectroscopy in both s- and p-polarization. By using the reversed Wentzel-Kramers-Brillouin approximation, the index profiles were describe...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3443796
更新日期:2010-05-01 00:00:00
abstract::Polarized Raman spectroscopy allows measurement of molecular orientation and composition and is widely used in the study of polymer systems. Here, we extend the technique to the extraction of quantitative orientation information from bone tissue, which is optically thick and highly turbid. We discuss multiple scatteri...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3426310
更新日期:2010-05-01 00:00:00
abstract::We experimentally study potential mechanisms by which the enhancement factor in low-coherence enhanced backscattering (LEBS) can probe subtle variations in radial intensity distribution in weakly scattering media. We use enhanced backscattering of light by implementing either (1) low spatial coherence illumination or ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3443795
更新日期:2010-05-01 00:00:00
abstract::Fluorescence image-guided surgery (FIGS) is an emerging technique in oncology, neurology, and cardiology. To adapt intraoperative imaging for various surgical applications, increasingly flexible and compact FIGS instruments are necessary. We present a compact, portable FIGS system and demonstrate its use in cardiovasc...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3378128
更新日期:2010-03-01 00:00:00
abstract::Previous research correcting for variable speed of sound in photoacoustic tomography (PAT) based on a generalized radon transform (GRT) model assumes first-order geometrical acoustics (GA) approximation. In the GRT model, the pressure is related to the optical absorption, in an acoustically inhomogeneous medium, throu...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3333550
更新日期:2010-03-01 00:00:00
abstract::A photoacoustic imaging system that incorporates a commercial ultrasonic camera for real-time imaging of two-dimensional (2-D) projection planes in tissue at video rate (30 Hz) is presented. The system uses a Q-switched frequency-doubled Nd:YAG pulsed laser for photoacoustic generation. The ultrasonic camera consists ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3420079
更新日期:2010-03-01 00:00:00
abstract::Fluorescence lifetime imaging (FLi) could potentially improve exogenous near-infrared (NIR) fluorescence imaging, because it offers the capability of discriminating a signal of interest from background, provides real-time monitoring of a chemical environment, and permits the use of several different fluorescent dyes h...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3368997
更新日期:2010-03-01 00:00:00
abstract::The main curative therapy for patients with nonsmall cell lung cancer is surgery. Despite this, the survival rate is only 50%, therefore it is important to more efficiently diagnose and predict prognosis for lung cancer patients. Raman spectroscopy is useful in the diagnosis of malignant and premalignant lesions. The ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3323088
更新日期:2010-03-01 00:00:00